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Nature Chemical Biology 4, 650 - 651 (2008)
doi:10.1038/nchembio1108-650
To dislodge an enzyme from an ion channel, try steroids
Susy C Kohout1 & Ehud Y Isacoff1
- Susy C. Kohout and Ehud Y. Isacoff are in the Department of Molecular and Cell Biology, University of California, Berkeley, and Divisions of Material and Physical Bioscience, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. e-mail: ehud@berkeley.edu
Abstract
Voltage-gated K+ channels assemble into complexes with Kv
s, a group of aldoketoreductases. The Kvs regulate channel gating and localization, and voltage-dependent changes in the channel regulate AKR activity. Pan and colleagues now propose a new type of modulation of this complex. Cortisone disrupts the complex and relieves channel inactivation—which should reduce neuronal excitability.
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RESEARCH
Cortisone dissociates the Shaker family K + channels from their β subunitsNature Chemical Biology Article (01 Nov 2008)
