Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
News and Views
Nature Chemical Biology 4, 581–582 (1 October 2008) | doi:10.1038/nchembio1008-581
New mechanism for a classic folate inhibitor
Abstract
Folate, one of the water-soluble forms of vitamin B9, is essential for the synthesis of DNA and RNA. It has long been known that processes involving rapidly proliferating cells, including embryogenesis and cancer, are particularly sensitive to folate levels, and drugs that interfere with folate metabolism, such as methotrexate, are used to treat cancer.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
