In this issue - pv

doi:10.1038/nchembio1008-v

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Data shown - p575

doi:10.1038/nchembio1008-575

'Data not shown' is an outdated caveat that obscures the transparency of a scientific report and weakens the peer review process.

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Inquiry-based and research-based laboratory pedagogies in undergraduate science - pp577 - 580

Gabriela C Weaver, Cianán B Russell & Donald J Wink

doi:10.1038/nchembio1008-577

Undergraduate research experiences help retain students in science majors and prepare our workforce for increasingly competitive jobs. Course-based approaches to research and inquiry allow educators to reach larger numbers of students and provide an entry into further research experiences.

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New mechanism for a classic folate inhibitor - pp581 - 582

H Alex Brown

doi:10.1038/nchembio1008-581

Metabolomics reveals new insights into the mechanism of an antimicrobial agent and folate metabolism.

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See also: Article by Kwon et al.

A bacterial copper metallothionein - pp582 - 583

Nigel J Robinson

doi:10.1038/nchembio1008-582

Metallothioneins sequester cadmium and surplus atoms of copper and zinc to prevent aberrant metal-catalyzed reactions. The identification of a 'cryptic' copper metallothionein in the bacterium that causes tuberculosis suggests that bacterial metallothioneins may be more widespread than previously suspected.

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See also: Article by Gold et al.

Small molecules can have big effects on endurance - pp583 - 584

Keith Baar & D Grahame Hardie

doi:10.1038/nchembio1008-583

Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.

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Raging hormones in plants - pp584 - 586

Eran Pichersky

doi:10.1038/nchembio1008-584

The strigolactones, a known class of plant metabolites, have now been shown to constitute the long-sought hormone that suppresses lateral branch formation. These hormones are synthesized from a carotenoid precursor in the roots and transported to the shoots.

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Sugars stack up - pp586 - 587

Chad Tatko

doi:10.1038/nchembio1008-586

Sugar binding by a variety of biomolecules is generally assumed to rely on hydrogen bonding and ionic interactions. A new study shows that arene-carbohydrate interactions are enthalpically driven through nontraditional C-H type hydrogen bonds.

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Research highlights - p589

doi:10.1038/nchembio1008-589

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Corrigendum: An integrated platform of genomic assays reveals small-molecule bioactivities - p632

Shawn Hoon, Andrew M Smith, Iain M Wallace, Sundari Suresh, Molly Miranda, Eula Fung, Michael Proctor, Kevan M Shokat, Chao Zhang, Ronald W Davis, Guri Giaever, Robert P St Onge & Corey Nislow

doi:10.1038/nchembio1008-632

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