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Nature Chemical Biology 4, 583 - 584 (2008)
doi:10.1038/nchembio1008-583

Small molecules can have big effects on endurance

Keith Baar1 & D Grahame Hardie1

  1. Keith Baar and D. Grahame Hardie are in the Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
    e-mail: d.g.hardie@dundee.ac.uk

Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.

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