Charge pairing between neighboring amphotericin B molecules inserted into the membrane is believed to significantly stabilize supramolecular channel architecture. Now the synthetic “knockout” of a carboxylic acid in amphotericin B, generated in an exacting ten-step chemical sequence, shows this interaction is not required for function.
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Kozmin, S. Chemical “knockout” challenges the amphotericin B channel model. Nat Chem Biol 4, 19–20 (2008). https://doi.org/10.1038/nchembio0108-19
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DOI: https://doi.org/10.1038/nchembio0108-19
