News and Views
Nature Chemical Biology 4, 21 - 22 (2008)
doi:10.1038/nchembio0108-21
What determines the speed limit on enzyme catalysis?
Hans Frauenfelder1
- Hans Frauenfelder is a Senior Fellow in the Theory Division (T10) at the Los Alamos National Laboratory, MS K710, Los Alamos, New Mexico 87545, USA. e-mail: frauenfelder@lanl.gov
Abstract
Though the chemical mechanisms of many enzymes have been elucidated, the mechanisms by which specificity and rate acceleration are achieved remain less explored. A new study suggests that physically controlled processes, such as active site access and organization, are rate limiting for enzymatic catalysis.
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