News and Views
Nature Chemical Biology 3, 535 - 536 (2007)
doi:10.1038/nchembio0907-535
The end defines the means in bacterial mRNA decay
Daniel R Schoenberg1
- Daniel R. Schoenberg is in the Department of Molecular & Cellular Biochemistry, The Ohio State University, 1645 Neil Ave., Columbus, Ohio 43210, USA. e-mail: schoenberg.3@osu.edu
Abstract
Bacterial mRNAs begin with a triphosphate on the first transcribed nucleotide, but RNase E, the endonuclease long thought to initiate mRNA decay in Escherichia coli, only works well on RNA with a 5'-monophosphate. Conversion of the 5'-triphosphate to a monophosphate now appears to be the first committed step in mRNA decay in E. coli.
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