News and Views
Nature Chemical Biology 3, 533 - 535 (2007)
doi:10.1038/nchembio0907-533
Targeting the spliceosome
Brian Rymond1
- Brian Rymond is in the Department of Biology, University of Kentucky, Lexington, Kentucky 40506-0225, USA. e-mail: rymond@uky.edu
Abstract
The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivoNature Medicine Letter (01 Jun 2005)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNANature Chemical Biology Article (01 Sep 2007)
A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicingThe EMBO Journal Article (17 Apr 2000)
See all 24 matches for Research
