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Nature Chemical Biology 3, 533 - 535 (2007)
doi:10.1038/nchembio0907-533

Targeting the spliceosome

Brian Rymond1

  1. Brian Rymond is in the Department of Biology, University of Kentucky, Lexington, Kentucky 40506-0225, USA. e-mail: rymond@uky.edu

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.

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