Brief Communication abstract
Nature Chemical Biology 3, 557 - 558 (2007)
Published online: 12 August 2007 | doi:10.1038/nchembio.2007.22
Enzymatic total synthesis of enterocin polyketides
Qian Cheng1,2, Longkuan Xiang2, Miho Izumikawa2, Dario Meluzzi3 & Bradley S Moore1,2,3
Polyketides are clinically important natural products that often require elaborate organic syntheses owing to their complex chemical structures. Here we report the multienzyme total synthesis of the Streptomyces maritimus enterocin and wailupemycin bacteriostatic agents in a single reaction vessel from simple benzoate and malonate substrates. To our knowledge, our results represent the first in vitro assembly of a complete type II polyketide synthase enzymatic pathway to natural products.
- Scripps Institution of Oceanograph, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, USA.
- College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, USA.
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Correspondence to: Bradley S Moore1,2,3 e-mail: bsmoore@ucsd.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Natural product biosynthesis moves in vitroNature Chemical Biology News and Views (01 Sep 2007)
The Lego-ization of polyketide biosynthesisNature Biotechnology News and Views (01 Sep 2005)
RESEARCH
Bactericidal antisense effects of peptide?PNA conjugatesNature Biotechnology Research (01 Apr 2001)
Diverse compounds mimic Alzheimer disease?causing mutations by augmenting Aβ42 productionNature Medicine Article (01 Jun 2005)
