Commentary
Nature Chemical Biology 3, 438 - 441 (2007)
doi:10.1038/nchembio0807-438
Reporting data from high-throughput screening of small-molecule libraries
James Inglese1, Caroline E Shamu2 & R Kiplin Guy3
- James Inglese is at the US National Institutes of Health Chemical Genomics Center, National Human Genome Institute, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3370, USA. e-mail: jinglese@mail.nih.gov
- Caroline E. Shamu is at the ICCB-Longwood Screening Facility, Harvard Medical School, 250 Longwood Ave., Boston, Massachusetts 02115, USA.
- R. Kiplin Guy is in the Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, North Lauderdale, Memphis, Tennessee 38105, USA.
Abstract
Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.
