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Nature Chemical Biology 3, 374 - 375 (2007)
doi:10.1038/nchembio0707-374
Cofactor-independent oxygenases go it alone
Susanne Fetzner1
- Susanne Fetzner is in the Institute of Molecular Microbiology and Biotechnology, Westfalian Wilhelms University Muenster, Corrensstrasse 3, 48149 Muenster, Germany. e-mail: fetzner@uni-muenster.de
Abstract
Oxygenases have long been thought to require a cofactor for catalysis. The structure of a vancomycin biosynthetic enzyme in complex with a substrate analog, and with molecular oxygen bound in its active site, supports the idea that cofactor-independent oxygenases act by mediating direct single-electron transfer from a substrate anion to dioxygen.
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RESEARCH
Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesisNature Letters to Editor (17 May 2007)
