In this issue - pv
doi:10.1038/nchembio0607-v
Table of contents
June 2007, Volume 3 No 6 pp297-349
About the coverTop of page
Editorial
A new look for chemical information - p297
doi:10.1038/nchembio0607-297
Nature Chemical Biology is committed to enhancing interdisciplinary communication and features online content to increase the accessibility of chemical information for our readers.
Full Text - A new look for chemical information | PDF (354 KB) - A new look for chemical information
Top of page
Commentary
Diversity in chemistry: catalyzing change - pp299 - 302
Irving R Epstein
doi:10.1038/nchembio0607-299
African Americans, Hispanics and Native Americans are significantly underrepresented in chemistry and related sciences. An innovative approach based on course revision, peer support, precollege training and strong mentoring offers promise for engaging and retaining more underrepresented minority students and more members of the majority population in these fields.
Full Text - Diversity in chemistry: catalyzing change | PDF (668 KB) - Diversity in chemistry: catalyzing change
Top of page
News and Views
A QUICk look at O-GlcNAc dynamics - pp303 - 304
Lance Wells
doi:10.1038/nchembio0607-303
In addition to expanding the chemical tools for exploring O-GlcNAc protein modifications, an innovative chemical biology approach has yielded new insights into the dynamic nature of this post-translational modification in the rodent brain.
Full Text - A QUICk look at O-GlcNAc dynamics | PDF (862 KB) - A QUICk look at O-GlcNAc dynamics
See also: Article by Khidekel et al.
Stimulating the cell's appetite for itself - pp304 - 306
Anne Simonsen & Harald Stenmark
doi:10.1038/nchembio0607-304
New inducers of autophagy—the process by which cells use lysosomes to degrade portions of their cytoplasm—are lead compounds for new drugs targeting neurodegenerative protein aggregation diseases.
Full Text - Stimulating the cell's appetite for itself | PDF (958 KB) - Stimulating the cell's appetite for itself
See also: Letter by Sarkar et al.
Smells like bread - pp306 - 307
David R Walt
doi:10.1038/nchembio0607-306
Mammalian olfactory receptor genes have been engineered into a yeast expression system. The resulting cells provide a high-throughput screening system for studying receptor specificity and may find use as biosensors.
Full Text - Smells like bread | PDF (807 KB) - Smells like bread
See also: Letter by Radhika et al.
A sugar-coated switch for cellular growth and arrest - pp307 - 309
Naoyuki Taniguchi
doi:10.1038/nchembio0607-307
The reversible attachment of an activated form of N-acetylglucosamine (UDP-GlcNAc) acts as a molecular switch between the growth and arrest of cells, establishing a new role for cell surface glycans.
Full Text - A sugar-coated switch for cellular growth and arrest | PDF (1,098 KB) - A sugar-coated switch for cellular growth and arrest
Sugars synthesized in a snap - pp309 - 310
Peng George Wang
doi:10.1038/nchembio0607-309
The chemical synthesis of natural oligosaccharides by sequentially stitching monosaccharides together remains a major challenge because of the complexity of carbohydrate structures. A recent paper reports a versatile technology for creating selectively protected synthetic intermediates, thus providing easy access to complex oligosaccharides.
Full Text - Sugars synthesized in a snap | PDF (713 KB) - Sugars synthesized in a snap
Research Highlights - p311
doi:10.1038/nchembio0607-311
Full Text - Research Highlights | PDF (353 KB) - Research Highlights
Top of page
Review
N-glycan structure dictates extension of protein folding or onset of disposal - pp313 - 320
Maurizio Molinari
doi:10.1038/nchembio880
Abstract - N-glycan structure dictates extension of protein folding or onset of disposal | Full Text - N-glycan structure dictates extension of protein folding or onset of disposal | PDF (667 KB) - N-glycan structure dictates extension of protein folding or onset of disposal
Top of page
Brief Communications
Introducing genetically encoded aldehydes into proteins - pp321 - 322
Isaac S Carrico, Brian L Carlson & Carolyn R Bertozzi
doi:10.1038/nchembio878
Abstract - Introducing genetically encoded aldehydes into proteins | Full Text - Introducing genetically encoded aldehydes into proteins | PDF (470 KB) - Introducing genetically encoded aldehydes into proteins | Supplementary information | Chemical compounds
Diarylquinolines target subunit c of mycobacterial ATP synthase - pp323 - 324
Anil Koul, Najoua Dendouga, Karen Vergauwen, Brenda Molenberghs, Luc Vranckx, Rudy Willebrords, Zorica Ristic, Holger Lill, Ismet Dorange, Jerome Guillemont, Dirk Bald & Koen Andries
doi:10.1038/nchembio884
Abstract - Diarylquinolines target subunit c of mycobacterial ATP synthase | Full Text - Diarylquinolines target subunit c of mycobacterial ATP synthase | PDF (434 KB) - Diarylquinolines target subunit c of mycobacterial ATP synthase | Supplementary information | Chemical compounds
Top of page
Letters
Chemical sensing of DNT by engineered olfactory yeast strain - pp325 - 330
Venkat Radhika, Tassula Proikas-Cezanne, Muralidharan Jayaraman, Djamila Onesime, Ji Hee Ha & Danny N Dhanasekaran
doi:10.1038/nchembio882
First Paragraph - Chemical sensing of DNT by engineered olfactory yeast strain | Full Text - Chemical sensing of DNT by engineered olfactory yeast strain | PDF (621 KB) - Chemical sensing of DNT by engineered olfactory yeast strain | Supplementary information | Chemical compounds
See also: News and Views by Walt
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models - pp331 - 338
Sovan Sarkar, Ethan O Perlstein, Sara Imarisio, Sandra Pineau, Axelle Cordenier, Rebecca L Maglathlin, John A Webster, Timothy A Lewis, Cahir J O'Kane, Stuart L Schreiber & David C Rubinsztein
doi:10.1038/nchembio883
First Paragraph - Small molecules enhance autophagy and reduce toxicity in Huntington's disease models | Full Text - Small molecules enhance autophagy and reduce toxicity in Huntington's disease models | PDF (622 KB) - Small molecules enhance autophagy and reduce toxicity in Huntington's disease models | Supplementary information | Chemical compounds
See also: News and Views by Simonsen & Stenmark
Top of page
Article
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics - pp339 - 348
Nelly Khidekel, Scott B Ficarro, Peter M Clark, Marian C Bryan, Danielle L Swaney, Jessica E Rexach, Yi E Sun, Joshua J Coon, Eric C Peters & Linda C Hsieh-Wilson
doi:10.1038/nchembio881
Abstract - Probing the dynamics of : O: -GlcNAc glycosylation in the brain using quantitative proteomics | Full Text - Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics | PDF (664 KB) - Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics | Supplementary information | Chemical compounds
See also: News and Views by Wells
Top of page
Top of pageCorrigendum
Corrigendum: Molecular imaging of hydrogen peroxide produced for cell signaling - p349
Evan W Miller, Orapim Tulyathan, Ehud Y Isacoff & Christopher J Chang
doi:10.1038/nchembio0607-349
Full Text - Corrigendum: Molecular imaging of hydrogen peroxide produced for cell signaling | PDF (318 KB) - Corrigendum: Molecular imaging of hydrogen peroxide produced for cell signaling
