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Letter
Nature Chemical Biology 3, 331–338 (1 June 2007) | doi:10.1038/nchembio883
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
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Abstract
The target of rapamycin proteins regulate various cellular processes including autophagy, which may play a protective role in certain neurodegenerative and infectious diseases. Here we show that a primary small-molecule screen in yeast yields novel small-molecule modulators of mammalian autophagy.
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