Supplementary information
From the following article
Chemical genetics reveals a complex functional ground state of neural stem cells
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers & Peter B Dirks
Nature Chemical Biology 3, 268 - 273 (2007) Published online: 8 April 2007
doi:10.1038/nchembio873
Supplementary Fig. 1
Bioactive neuromodulators display a rich intraclass chemical diversity.
Supplementary Fig. 2
SAR analysis of adenosine and serotonin agonists.
Supplementary Fig. 3
SAR analysis of dopamine agonists and antagonists.
Supplementary Table 1
HTS of neural precursor cells.
Supplementary Table 2
HTS bioactive pharmacological classes.
Supplementary Table 3
Assessment of the potency and selectivity of a subset of the identified bioactive agents.
Supplementary Table 4
Normal and cancerous human neural precursor cells show sensitivity to a myriad of neurotransmission modulators.
Supplementary Methods
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