In this issue - pv

doi:10.1038/nchembio0507-v

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Catalyzing collaboration - p239

doi:10.1038/nchembio0507-239

Facilitating interdisciplinary collaboration is essential for the success of chemical biology.

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EuCheMS - p241

Joanne Kotz

doi:10.1038/nchembio0507-241

The newly formed European Association for Chemical and Molecular Sciences is bridging national cultures to bring European chemists together.

Full Text - EuCheMS | PDF (335 KB) - EuCheMS

Assembling iron-sulfur clusters in the cytosol - pp243 - 244

Joan B Broderick

doi:10.1038/nchembio0507-243

Two proteins that together serve as a scaffold for iron-sulfur cluster assembly in the yeast cytosol have been identified, providing the first mechanistic insight into cytosolic cluster assembly.

Full Text - Assembling iron-sulfur clusters in the cytosol | PDF (637 KB) - Assembling iron-sulfur clusters in the cytosol

See also: Article by Netz et al.

Measuring H₂O₂ produced in response to cell surface receptor activation - pp244 - 246

Sue Goo Rhee

doi:10.1038/nchembio0507-244

Quantitative detection of H₂O₂, which is increasingly recognized as an intracellular messenger, remains a challenge for cell biologists. The development of molecular probes that fluoresce upon H₂O₂-mediated removal of a boronate-based protecting group, rather than upon nonspecific oxidation, demonstrates that this challenge is not insurmountable.

Full Text - Measuring H2O2 produced in response to cell surface receptor activation | PDF (522 KB) - Measuring H2O2 produced in response to cell surface receptor activation

See also: Letter by Miller et al.

Chemical probes of neural stem cell self-renewal - pp246 - 247

Mark Mercola

doi:10.1038/nchembio0507-246

A chemical-genetic study indicates that modulation of neurotransmitter signaling affects the self-renewal capacity of neural stem cells in culture. Although the mechanisms of action are not resolved, the research points to a potential therapeutic target class for treatment of brain tumors.

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See also: Letter by Diamandis et al.

High-throughput screening flows along - pp247 - 249

Hicham Fenniri & Ramon Alvarez-Puebla

doi:10.1038/nchembio0507-247

Simultaneous measurement of multiple analytes in high-throughput assays requires the design of integrated sensory elements. The latest development in this field is an engineering masterpiece based on microfluidics, photolithography and polymer science.

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Methyllysine analogs: rewriting the code - pp249 - 250

Monica Bhatia & Paul R Thompson

doi:10.1038/nchembio0507-249

Lysine methylation has been implicated in gene transcription and epigenetic control. Chemical modification of cysteine residues results in a highly similar structural and functional analog of methylated lysine and provides a means to study this important modification in nucleosomes.

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Research Highlights - p251

doi:10.1038/nchembio0507-251

Full Text - Research Highlights | PDF (371 KB) - Research Highlights