Table 1
From the following article
Chemical genetics reveals a complex functional ground state of neural stem cells
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers & Peter B Dirks
Nature Chemical Biology 3, 268 - 273 (2007) Published online: 8 April 2007
doi:10.1038/nchembio873
Table 1. HTS bioactive pharmacological classes
| Classa | Active agentsb | Total agents | % active in class |
|---|---|---|---|
a Includes all classes with a percentage active in class of at least 10%. | |||
b Only includes inhibitors. | |||
c Includes antibiotics, apoptosis, cell cycle, cell stress, cytoskeleton and DNA agents. | |||
d Frequency of whole screen. | |||
| Cytotoxicc | 38 | 114 | 33 |
| Biochemistry | 6 | 46 | 13 |
| Cannabinoid | 1 | 6 | 17 |
| Cholinergic | 8 | 77 | 10 |
| Cyclic nucleotides | 4 | 31 | 13 |
| Dopamine | 22 | 113 | 20 |
| Glutamate | 9 | 88 | 10 |
| Intracellular Ca2+ | 2 | 7 | 29 |
| Ion pump | 3 | 16 | 19 |
| Lipid | 1 | 9 | 11 |
| Na+ channel | 3 | 17 | 18 |
| Nitric oxide | 5 | 37 | 14 |
| Opioid | 6 | 27 | 22 |
| P2 receptor | 2 | 14 | 14 |
| Phosphorylation | 9 | 93 | 10 |
| Serotonin | 12 | 83 | 14 |
| Vanilloid | 2 | 5 | 40 |
| Entire screen | 160 | 1,267 | 13d |
