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Nature Chemical Biology 3, 249 - 250 (2007)
doi:10.1038/nchembio0507-249
Methyllysine analogs: rewriting the code
Monica Bhatia1 & Paul R Thompson1
- Monica Bhatia and Paul R. Thompson are in the Chemistry and Biochemistry Department, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA. e-mail: thompson@mail.chem.sc.edu
Abstract
Lysine methylation has been implicated in gene transcription and epigenetic control. Chemical modification of cysteine residues results in a highly similar structural and functional analog of methylated lysine and provides a means to study this important modification in nucleosomes.
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