In this issue - pv

doi:10.1038/nchembio0407-v

Full Text - In this issue | PDF (1,486 KB) - In this issue

Keeping it real - p185

doi:10.1038/nchembio0407-185

Scientific endeavors benefit from transparency and open declarations of real or perceived conflicts of interest.

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What's wrong with drug screening today - pp187 - 191

Garry P Nolan

doi:10.1038/nchembio0407-187

Drug screening in the immediate term will be best accomplished by early use of primary cells in which the target of the screen is a network of proteins measured in populations of single cells.

Full Text - What's wrong with drug screening today | PDF (1,540 KB) - What's wrong with drug screening today

Molecule by molecule, the physics and chemistry of life: SMB 2007 - pp193 - 197

Steven M Block, Matthew H Larson, William J Greenleaf, Kristina M Herbert, Nicholas R Guydosh & Peter C Anthony

doi:10.1038/nchembio0407-193

Interdisciplinary work in the life sciences at the boundaries of biology, chemistry and physics is making enormous strides. This progress was showcased at the recent Single Molecule Biophysics conference.

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Chemical biology at the Broad Institute - p199

Joanne Kotz

doi:10.1038/nchembio0407-199

The Broad Institute was founded with the vision of creating a truly collaborative biomedical research environment, and small molecules are a central focus.

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Self-reporting peptides illuminate the MHC groove - pp201 - 202

Jonathan W Yewdell & Avital Lev

doi:10.1038/nchembio0407-201

Synthetic oligopeptides chemically modified with environmentally sensitive fluorophores enable real-time visualization of peptide binding to MHC molecules. This technology will expand our understanding of antigen presentation and enable visualization of fluorescent peptide binding to a wide variety of receptors in living cells.

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See also: Letter by Venkatraman et al.

Adenosine triphosphate and thiamine cross paths - pp202 - 203

Frank Jordan

doi:10.1038/nchembio0407-202

Just when we thought that all of the interesting biochemical cofactors have been identified, a new metabolite consisting of thiamine and ATP has been isolated from a number of organisms.

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See also: Brief Communication by Bettendorff et al.

The rule of four - pp203 - 204

Bruce A Armitage

doi:10.1038/nchembio0407-203

Guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The recent discovery of quadruplex-forming sequences in the 5' untranslated regions of various proto-oncogenes suggests an important role for such sequences in inhibition of mRNA translation.

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See also: Letter by Kumari et al.

Focal adhesion: getting a grasp on myxobacterial gliding - pp205 - 206

Wenyuan Shi & Renate Lux

doi:10.1038/nchembio0407-205

The gliding motility of individual bacterial cells has been a deep mystery so far. Recent results provide the first molecular-level insights into the mechanism of this process.

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Iron-sulfur clusters as oxygen-responsive molecular switches - pp206 - 207

F Wayne Outten

doi:10.1038/nchembio0407-206

FNR is a global regulator of the Escherichia coli aerobic-anaerobic growth transition and relies on an [Fe-S] cluster cofactor to control its oxygen-dependent activity. Details of the chemical reaction of oxygen with the [Fe-S] cluster reveal how this cofactor is used for oxygen sensing.

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Research Highlights - p209

doi:10.1038/nchembio0407-209

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