Brief Communication abstract
Nature Chemical Biology 3, 211 - 212 (2007)
Published online: 4 March 2007 | doi:10.1038/nchembio867
Discovery of a natural thiamine adenine nucleotide
Lucien Bettendorff1,4, Barbara Wirtzfeld1,4, Alexander F Makarchikov1, Gabriel Mazzucchelli2, Michel Frédérich3, Tiziana Gigliobianco1, Marjorie Gangolf1, Edwin De Pauw2, Luc Angenot3 & Pierre Wins1
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
- Center for Cellular and Molecular Neurobiology, University of Liège, Avenue de l'Hôpital 1, B-4000 Liège, Belgium.
- Department of Physical Chemistry, University of Liège, Allée de la Chimie 3, B-4000 Liège, Belgium.
- Laboratory of Pharmacognosy, Drug Research Center, University of Liège, Avenue de l'Hôpital 1, B-4000 Liège, Belgium.
- These authors contributed equally to this work.
Correspondence to: Lucien Bettendorff1,4 e-mail: l.bettendorff@ulg.ac.be
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Adenosine triphosphate and thiamine cross pathsNature Chemical Biology News and Views (01 Apr 2007)
