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Nature Chemical Biology 3, 203 - 204 (2007)
doi:10.1038/nchembio0407-203
The rule of four
Bruce A Armitage1
- Bruce A. Armitage is in the Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213-3890, USA. e-mail: army@andrew.cmu.edu
Abstract
Guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The recent discovery of quadruplex-forming sequences in the 5' untranslated regions of various proto-oncogenes suggests an important role for such sequences in inhibition of mRNA translation.
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RESEARCH
Scanning of guanine?guanine mismatches in DNA by synthetic ligands using surface plasmon resonanceNature Biotechnology Research (01 Jan 2001)
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translationNature Chemical Biology Letter (01 Apr 2007)
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