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Letter
Nature Chemical Biology 3, 156–160 (1 March 2007) | doi:10.1038/nchembio859
A clickable inhibitor reveals context-dependent autoactivation of p90 RSK
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Abstract
p90 ribosomal protein S6 kinases (RSKs) integrate upstream signals through two catalytic domains. Autophosphorylation of Ser386 by the regulatory C-terminal kinase domain (CTD) is thought to be essential for activation of the N-terminal kinase domain (NTD), which phosphorylates multiple downstream targets.
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