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Brief Communication
Nature Chemical Biology 3, 154–155 (1 March 2007) | doi:10.1038/nchembio858
Small-molecule regulation of zebrafish gene expression
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Abstract
The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics.
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