Brief Communication abstract
Nature Chemical Biology 3, 154 - 155 (2007)
Published online: 21 January 2007 | doi:10.1038/nchembio858
Small-molecule regulation of zebrafish gene expression
Hanife Esengil1, Vicky Chang1, John K Mich1 & James K Chen1
The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.
- Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Center for Clinical Sciences Research, Room 3155, Stanford, California 94305, USA.
Correspondence to: James K Chen1 e-mail: jameschen@stanford.edu
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