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Nature Chemical Biology 3, 89 - 90 (2007)
doi:10.1038/nchembio0207-89
An RNA transcriptional regulator templates its own regulatory RNA
Jennifer F Kugel1 & James A Goodrich1
- Jennifer F. Kugel and James A. Goodrich are in the Department of Chemistry and Biochemistry, University of Colorado at Boulder, 215 UCB, Boulder, Colorado 80309–0215, USA. e-mail: james.goodrich@colorado.edu
Abstract
The bacterial transcriptional repressor 6S RNA mimics the DNA contained in a melted promoter and forms specific interactions with the active site of RNA polymerase. A new study shows that, surprisingly, 6S RNA acts as a template for the synthesis of small RNAs, which liberates the polymerase from 6S RNA. Hence, the transcriptional repressor 6S RNA serves as a template for the synthesis of its own de-repressive RNA.
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