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Nature Chemical Biology 3, 754–755 (1 December 2007) | doi:10.1038/nchembio1207-754

Chemical genetic modification of Ca2+ channel activity

Michael Nitabach

Because they regulate cellular Ca2+ influx, CaVs are key regulators of excitable cell function. Perhaps their most important role in neurons is in action potential–triggered presynaptic neurotransmitter release.