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Nature Chemical Biology 3, 759 (1 December 2007) | doi:10.1038/nchembio1207-759
Research Highlights
Abstract
Building a bigger haystack Combinatorial chemistry offers a powerful tool to create small-molecule libraries; however, the neccessity of screening to identify bioactive compounds limits the size and complexity of combinatorial library searches. In contrast, in vitro evolution strategies have permitted selection for functional nucleic acids and proteins with larger library scales and diversities.
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