Multimodular scaffold proteins are ideally suited for assembling the various proteins in signaling pathways into supramolecular complexes. A recent study demonstrates that, in addition to a passive scaffolding role, a PDZ domain in a photoreceptor scaffold protein actively regulates fruit fly visual signaling via light-dependent conformational cycling.
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Wei Feng
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Zhang, M. Scaffold proteins as dynamic switches. Nat Chem Biol 3, 756–757 (2007). https://doi.org/10.1038/nchembio1207-756
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DOI: https://doi.org/10.1038/nchembio1207-756
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