News and Views
Nature Chemical Biology 3, 756 - 757 (2007)
doi:10.1038/nchembio1207-756
Scaffold proteins as dynamic switches
Mingjie Zhang1
- Mingjie Zhang is in the Department of Biochemistry, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China. e-mail: mzhang@ust.hk
Abstract
Multimodular scaffold proteins are ideally suited for assembling the various proteins in signaling pathways into supramolecular complexes. A recent study demonstrates that, in addition to a passive scaffolding role, a PDZ domain in a photoreceptor scaffold protein actively regulates fruit fly visual signaling via light-dependent conformational cycling.
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