In this issue - pv
doi:10.1038/nchembio1207-v
Table of contents
December 2007, Volume 3 No 12 pp737-804
- In This Issue
- Editorial
- Commentary
- Meeting Report
- Elements
- News and Views
- Brief Communication
- Letters
- Articles
Top of page
Editorial
Those who can teach, should - p737
doi:10.1038/nchembio1207-737
Education is a central mission of universities. Emphasizing creative and passionate teaching by all academic staff is essential for maintaining educational quality while supporting vigorous research.
Full Text - Those who can teach, should | PDF (1,414 KB) - Those who can teach, should
Top of page
Commentary
Recognizing and exploiting differences between RNAi and small-molecule inhibitors - pp739 - 744
William A Weiss, Stephen S Taylor & Kevan M Shokat
doi:10.1038/nchembio1207-739
The biology of RNA interference has greatly facilitated analysis of loss-of-function phenotypes, but correlating these phenotypes with small-molecule inhibition profiles is not always straightforward. We examine the rationale of comparing RNA interference to pharmacological intervention in chemical biology.
Full Text - Recognizing and exploiting differences between RNAi and small-molecule inhibitors | PDF (2,124 KB) - Recognizing and exploiting differences between RNAi and small-molecule inhibitors
Top of page
Meeting Report
Understanding the chemical mechanisms of life - pp745 - 749
Barbara Nawrot & Elena Gaggelli
doi:10.1038/nchembio1207-745
Abstract - Understanding the chemical mechanisms of life | Full Text - Understanding the chemical mechanisms of life | PDF (1,840 KB) - Understanding the chemical mechanisms of life
Top of page
Elements
Sustainable Sciences Institute - p751
Joanne Kotz
doi:10.1038/nchembio.2007.500
The Sustainable Sciences Institute is building the capacity of scientists in the developing world to address local problems.
Full Text - Sustainable Sciences Institute | PDF (1,458 KB) - Sustainable Sciences Institute
Top of page
News and Views
Understanding DNA-based catalysis one molecule at a time - pp753 - 754
Kenny Schlosser & Yingfu Li
doi:10.1038/nchembio1207-753
DNA is the newest member of the enzyme club. The first glimpse of DNAzyme conformational changes at the single-molecule level reveals that enzymes made of DNA can use the same modi operandi as protein and RNA catalysts.
Full Text - Understanding DNA-based catalysis one molecule at a time | PDF (2,773 KB) - Understanding DNA-based catalysis one molecule at a time
See also: Letter by Kim et al.
Chemical genetic modification of Ca2+ channel activity - pp754 - 755
Michael Nitabach
doi:10.1038/nchembio1207-754
Pharmacological and genetic modulators of voltage-gated Ca2+ channel (CaV) activity have been useful tools for understanding and modulating excitable cell function. A new method combines these approaches to provide pharmacological control of a genetically encoded suppressor of CaV activity.
Full Text - Chemical genetic modification of Ca2+ channel activity | PDF (2,982 KB) - Chemical genetic modification of Ca2+ channel activity
See also: Article by Yang et al.
Scaffold proteins as dynamic switches - pp756 - 757
Mingjie Zhang
doi:10.1038/nchembio1207-756
Multimodular scaffold proteins are ideally suited for assembling the various proteins in signaling pathways into supramolecular complexes. A recent study demonstrates that, in addition to a passive scaffolding role, a PDZ domain in a photoreceptor scaffold protein actively regulates fruit fly visual signaling via light-dependent conformational cycling.
Full Text - Scaffold proteins as dynamic switches | PDF (2,943 KB) - Scaffold proteins as dynamic switches
Research Highlights - p759
doi:10.1038/nchembio1207-759
Full Text - Research Highlights | PDF (1,452 KB) - Research Highlights
Top of page
Brief Communication
Enzymatic catalysis on conducting graphite particles - pp761 - 762
Kylie A Vincent, Xiang Li, Christopher F Blanford, Natalie A Belsey, Joel H Weiner & Fraser A Armstrong
doi:10.1038/nchembio.2007.47
Abstract - Enzymatic catalysis on conducting graphite particles | Full Text - Enzymatic catalysis on conducting graphite particles | PDF (1,512 KB) - Enzymatic catalysis on conducting graphite particles | Supplementary information | Chemical compounds
Top of page
Letters
Dissecting metal ion–dependent folding and catalysis of a single DNAzyme - pp763 - 768
Hee-Kyung Kim, Ivan Rasnik, Juewen Liu, Taekjip Ha & Yi Lu
doi:10.1038/nchembio.2007.45
First Paragraph - Dissecting metal ion-dependent folding and catalysis of a single DNAzyme | Full Text - Dissecting metal ion–dependent folding and catalysis of a single DNAzyme | PDF (1,695 KB) - Dissecting metal ion–dependent folding and catalysis of a single DNAzyme | Supplementary information
See also: News and Views by Schlosser & Li
Control of protein phosphorylation with a genetically encoded photocaged amino acid - pp769 - 772
Edward A Lemke, Daniel Summerer, Bernhard H Geierstanger, Scott M Brittain & Peter G Schultz
doi:10.1038/nchembio.2007.44
First Paragraph - Control of protein phosphorylation with a genetically encoded photocaged amino acid | Full Text - Control of protein phosphorylation with a genetically encoded photocaged amino acid | PDF (1,618 KB) - Control of protein phosphorylation with a genetically encoded photocaged amino acid | Supplementary information | Chemical compounds
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate - pp773 - 778
Martha L Escobar Galvis, Juan Jia, Xiao Zhang, Nadja Jastrebova, Dorothe Spillmann, Eva Gottfridsson, Toin H van Kuppevelt, Eyal Zcharia, Israel Vlodavsky, Ulf Lindahl & Jin-Ping Li
doi:10.1038/nchembio.2007.41
First Paragraph - Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate | Full Text - Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate | PDF (1,802 KB) - Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate | Supplementary information | Chemical compounds
Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH - pp779 - 784
Nathan W Luedtke, Rachel J Dexter, Daniel B Fried & Alanna Schepartz
doi:10.1038/nchembio.2007.49
First Paragraph - Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH | Full Text - Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH | PDF (1,648 KB) - Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH | Supplementary information | Chemical compounds
Top of page
Top of pageArticles
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin - pp785 - 794
Swati Basu, Rozalina Grubina, Jinming Huang, Jeanet Conradie, Zhi Huang, Anne Jeffers, Alice Jiang, Xiaojun He, Ivan Azarov, Ryan Seibert, Atul Mehta, Rakesh Patel, Stephen Bruce King, Neil Hogg, Abhik Ghosh, Mark T Gladwin & Daniel B Kim-Shapiro
doi:10.1038/nchembio.2007.46
Abstract - Catalytic generation of N: 2: O: 3: by the concerted nitrite reductase and anhydrase activity of hemoglobin | Full Text - Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin | PDF (1,953 KB) - Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin | Supplementary information | Chemical compounds
Genetically encoded molecules for inducibly inactivating CaV channels - pp795 - 804
Tingting Yang, Yasir Suhail, Stanislava Dalton, Timothy Kernan & Henry M Colecraft
doi:10.1038/nchembio.2007.42
Abstract - Genetically encoded molecules for inducibly inactivating Ca: V: channels | Full Text - Genetically encoded molecules for inducibly inactivating CaV channels | PDF (2,017 KB) - Genetically encoded molecules for inducibly inactivating CaV channels | Supplementary information | Chemical compounds
See also: News and Views by Nitabach
