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Letter

Nature Chemical Biology 3, 716–721 (1 November 2007) | doi:10.1038/nchembio.2007.32

Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated

Yang Zhao , Tszfung F Chow , Rachel S Puckrin , Simon E Alfred , Albert K Korir , Cynthia K Larive & Sean R Cutler

Natural variation in human drug metabolism and target genes can cause pharmacogenetic or interindividual variation in drug sensitivity. We reasoned that natural pharmacogenetic variation in model organisms could be systematically exploited to facilitate the characterization of new small molecules.