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Nature Chemical Biology 3, 689 - 690 (2007)
doi:10.1038/nchembio1107-689

Phosphorothioation of DNA in bacteria

Fritz Eckstein1

  1. Fritz Eckstein is at the Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Str. 3, 37075 Goettingen, Germany. e-mail: eckstein@em.mpg.de


A phosphorothioate modification of DNA has been identified in bacteria. This first observed alteration of the DNA phosphate backbone opens many questions about the mechanism of sulfur incorporation and the function of this modification.

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