News and Views
Nature Chemical Biology 3, 687 - 688 (2007)
doi:10.1038/nchembio1107-687
Nitrated cyclic GMP as a new cellular signal
Martin Feelisch1
- Martin Feelisch is at the Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. e-mail: mf@warwick.ac.uk
Abstract
Nitric oxide–mediated production of cyclic guanosine 3',5'-monophosphate (cGMP) is a crucial signal transduction pathway that controls a wide array of biological functions. A new layer of complexity in mammalian cell regulation is revealed by the discovery of a redox-active nitrated cGMP derivative with the ability to post-translationally modify protein thiol residues by S-guanylation.
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