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Letter
Nature Chemical Biology 3, 44–49 (1 January 2007) | doi:10.1038/nchembio842
Antibacterial lysine analogs that target lysine riboswitches
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Abstract
Lysine riboswitches are bacterial RNA structures that sense the concentration of lysine and regulate the expression of lysine biosynthesis and transport genes. Members of this riboswitch class are found in the 5|[prime]| untranslated region of messenger RNAs, where they form highly selective receptors for lysine.
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