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Letter
Nature Chemical Biology 3, 55–59 (1 January 2007) | doi:10.1038/nchembio833
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
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Abstract
Insulin and insulin-like growth factor have an essential role in growth, development and the maintenance of metabolic homeostasis, including glucose uptake from the bloodstream. Researchers have identified mutations in insulin receptors that cause severe insulin resistance, and a temperature-sensitive daf-2 (a gene encoding an insulin receptor–like protein) mutant in Caenorhabditis elegans has served as an insulin resistance model.
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