News and Views
Nature Chemical Biology 3, 20 - 21 (2007)
doi:10.1038/nchembio0107-20
Sensing RNA virus infections
Christopher F Basler1 & Adolfo García-Sastre1
- Christopher F. Basler and Adolfo García-Sastre are in the Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA. e-mail: adolfo.garcia-sastre@mssm.edu
Abstract
RIG-I is an RNA helicase that senses viral infections and triggers innate and adaptive immune mechanisms. Recent studies have identified RNAs bearing 5'-triphosphates as ligands of RIG-I and have suggested a mechanism for how RIG-I distinguishes viral RNA from host RNA.
