1. Francine B. Perler is at New England Biolabs, 240 County Road, Ipswich, Massachusetts 01938, USA. e-mail: perler@neb.com

Abstract

Imagine being able to rapidly switch on your favorite protein at a specified concentration, location and time in a live multicellular organism. Sounds like a dream? Recent advances in controlling protein splicing with small molecules are close to making it a reality.

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