1. Charles R. Lea is in the Department of Chemistry at the University of Chicago and Joseph A. Piccirilli is in the Departments of Chemistry and of Biochemistry and Molecular Biology and is an investigator in the Howard Hughes Medical Institute, Center for Integrative Science, University of Chicago, Chicago, Illinois 60637, USA. e-mail: jpicciri@uchicago.edu

Abstract

Drug-resistant bacteria are a growing challenge to world health, and new approaches to antibiotic development are needed. Riboswitches, regulatory elements of mRNA, are shown to be a potential new target for antibiotic drugs.

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