Supplementary information

From the following article

Systems biology and combination therapy in the quest for clinical efficacy

Jonathan B Fitzgerald, Birgit Schoeberl, Ulrik B Nielsen and Peter K Sorger

Nature Chemical Biology 2, 458-466 (2006)

doi:10.1038/nchembio817

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Supplementary Table 1

Species, parameters and reactions that can be used to recreate the mechanistic models for Figure 2 (two ligands, two inhibitors).

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Supplementary Table 2

Species, parameters and reactions that can be used to recreate the mechanistic models for Figure 3 (exclusive versus nonexclusive), Figure 4 (linear and ultrasensitive), Figure 5 (negative feedback) and Figure 6 (diseased linear and ultrasensitive).

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