Nitrite is an inorganic anion essential in cell signaling and vascular biology. A new study shows that the multicopper oxidase ceruloplasmin is critical for maintaining plasma nitrite, revealing a new link between copper and nitric oxide homeostasis.
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References
Gladwin, M.T. et al. Nat. Chem. Biol. 1, 308–314 (2005).
Hess, D.T., Matsumoto, A., Kim, S.O., Marshall, H.E. & Stamler, J.S. Nat. Rev. Mol. Cell Biol. 6, 150–166 (2005).
Bryan, N.S. et al. Nat. Chem. Biol. 1, 290–297 (2005).
Shiva, S. et al. Nat. Chem. Biol. 2, 486–493 (2006).
Hellman, N.E. & Gitlin, J.D. Annu. Rev. Nutr. 22, 439–458 (2002).
Harris, Z.L. et al. Proc. Natl. Acad. Sci. USA 92, 2539–2543 (1995).
Castello, P.R., David, P.S., McClure, T., Crook, Z. & Poyton, R.O. Cell Metab. 3, 277–287 (2006).
Klomp, L.W., Farhangrazi, Z.S., Dugan, L.L. & Gitlin, J.D. J. Clin. Invest. 98, 207–215 (1996).
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Samuel, T., Gitlin, J. Copper and nitric oxide meet in the plasma. Nat Chem Biol 2, 452–453 (2006). https://doi.org/10.1038/nchembio0906-452
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DOI: https://doi.org/10.1038/nchembio0906-452
