1. Tamika K. Samuel and Jonathan D. Gitlin are in the Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA. e-mail: gitlin@wustl.edu

Abstract

Nitrite is an inorganic anion essential in cell signaling and vascular biology. A new study shows that the multicopper oxidase ceruloplasmin is critical for maintaining plasma nitrite, revealing a new link between copper and nitric oxide homeostasis.

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