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Nature Chemical Biology 2, 449 - 450 (2006)
doi:10.1038/nchembio0906-449
Synthetic sugars enhance the functional glycomics toolkit
Jeremy E Turnbull1 & Robert J Linhardt2
- Jeremy E. Turnbull is in the School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, England L69 7ZB, UK. e-mail: j.turnbull@liverpool.ac.uk
- Robert J. Linhardt is at Rensselaer Polytechnic Institute, Biotechnology Center 4005, 110 8th Street, Troy, New York 12180, USA. e-mail: linhar@rpi.edu
Abstract
Glycosaminoglycan-protein interactions are an important frontier for discovering new mechanisms of cellular regulation by complex sugars. The integration of the 'chemical glycomics' strategies of synthetic chemistry, arrays and biological assays shows that the precise pattern of sugar sulfation dictates the specificity of a sugar's function.
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RESEARCH
Sulfation patterns of glycosaminoglycans encode molecular recognition and activityNature Chemical Biology Letter (01 Sep 2006)
