Supplementary information
From the following article
A clinical drug library screen identifies astemizole as an antimalarial agent
Curtis R Chong, Xiaochun Chen, Lirong Shi, Jun O Liu & David J Sullivan, Jr
Nature Chemical Biology 2, 415 - 416 (2006) Published online: 2 July 2006
doi:10.1038/nchembio806
Supplementary Fig. 1
Comparison of The Johns Hopkins Clinical Compound Library with other libraries of existing drugs.
Supplementary Fig. 2
Selected screening results from drug classes of interest.
Supplementary Fig. 3
Astemizole reversibly inhibits heme crystallization and accumulates in the P. falciparum food vacuole.
Supplementary Table 1
Existing drugs that showed >50% inhibition of 3D7 proliferation at 10
M.
Supplementary Methods
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