Supplementary information
From the following article
Coupling ligand structure to specific conformational switches in the
2-adrenoceptor
Xiaojie Yao, Charles Parnot, Xavier Deupi, Venkata R P Ratnala, Gayathri Swaminath, David Farrens & Brian Kobilka
Nature Chemical Biology 2, 417 - 422 (2006) Published online: 25 June 2006
doi:10.1038/nchembio801
Supplementary Fig. 1
Site-specific labeling of Cys271 in the
2-AR.
Supplementary Fig. 2
Isoproterenol binding to bimane-labeled
2-AR-
5-Cys271+Trp135.
Supplementary Table 1
Equilibrium dissociation constants for ligand binding to the
2-AR-
5-Cys271 and
2-AR-
5-Cys271+Trp135 receptors.
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