Supplementary information

From the following article

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

Xiaojie Yao, Charles Parnot, Xavier Deupi, Venkata R P Ratnala, Gayathri Swaminath, David Farrens & Brian Kobilka

Nature Chemical Biology 2, 417 - 422 (2006) Published online: 25 June 2006

doi:10.1038/nchembio801

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Supplementary Fig. 1

Site-specific labeling of Cys271 in the beta2-AR.

Supplementary Fig. 2

Isoproterenol binding to bimane-labeled beta2-AR-Delta5-Cys271+Trp135.

Supplementary Table 1

Equilibrium dissociation constants for ligand binding to the beta2-AR-Delta5-Cys271 and beta2-AR-Delta5-Cys271+Trp135 receptors.

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