Figure 1 - Identification of astemizole as an antimalarial agent by screening a library of existing drugs.
From the following article
A clinical drug library screen identifies astemizole as an antimalarial agent
Curtis R Chong, Xiaochun Chen, Lirong Shi, Jun O Liu & David J Sullivan, Jr
Nature Chemical Biology 2, 415 - 416 (2006) Published online: 2 July 2006
doi:10.1038/nchembio806
(a) Screening results for 2,687 existing drugs in the JHCCL organized by therapeutic indication as listed in the Merck Index. We incubated drugs at 10 
M final concentration; numeric guides to drug categories are available in Supplementary Figure 1. (b) Chemical structure of astemizole. (c,d) Astemizole and desmethylastemizole reduce parasitemias of mice infected with (c) chloroquine-sensitive P. vinckei (control n = 9; astemizole 30 mg m-2 n = 9, P = 0.00012; desmethylastemizole 15 mg m-2 n = 10, P = 0.00011; desmethylastemizole 30 mg m-2 n = 9, P = 4.8 
10-5) and (d) chloroquine-resistant P. yoelii (control n = 9; astemizole 15 mg m-2 n = 10, P = 0.085; astemizole 30 mg m-2 n = 9, P = 0.017; desmethylastemizole 15 mg m-2 n = 8, P = 0.0002). Data are presented as mean parasitemia 
s.e.m.
