Brief Communication abstract
Nature Chemical Biology 2, 415 - 416 (2006)
Published online: 2 July 2006 | doi:10.1038/nchembio806
A clinical drug library screen identifies astemizole as an antimalarial agent
Curtis R Chong1,2,3, Xiaochun Chen1, Lirong Shi4, Jun O Liu1,2,5 & David J Sullivan, Jr2,4
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.
- Department of Pharmacology and Molecular Sciences. The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
- The Johns Hopkins Clinical Compound Screening Initiative, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
- Medical Scientist Training Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
- The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
- Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Correspondence to: David J Sullivan, Jr2,4 e-mail: dsulliva@jhsph.edu
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