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Nature Chemical Biology 2, 398 - 400 (2006)
doi:10.1038/nchembio0806-398
Engineering Escherichia coli to produce nonribosomal peptide antibiotics
Gregory L Challis1
- Gregory L. Challis is in the Department of Chemistry at Warwick University, Gibbet Hill Road, Coventry CV4 7AL, UK. e-mail: g.l.challis@warwick.ac.uk
Abstract
Genetic manipulation of biosynthetic pathways is a useful method for producing analogs of complex bioactive metabolites, but this technique can be challenging when performed in the natural producer of the target compounds. Reconstruction of biosynthetic gene clusters in E. coli could be the key to rapid heterologous production of natural products and genetic manipulation of their biosynthetic pathways.
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RESEARCH
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coliNature Chemical Biology Letter (01 Aug 2006)
