Supplementary information
From the following article
Small molecule–based reversible reprogramming of cellular lifespan
Jaejoon Won, Mina Kim, Nuri Kim, Jin Hee Ahn, Woo Gil Lee, Sung Soo Kim, Ki-Young Chang, Yong-Weon Yi & Tae Kook Kim
Nature Chemical Biology 2, 369 - 374 (2006) Published online: 11 June 2006 Corrected online: 1 October 0613
doi:10.1038/nchembio800
Supplementary Fig. 1
Establishment of cellular senescence by overexpression of TRF2
BM.
Supplementary Fig. 2
Reversal of replicative senescence of BJ and HMEC cells by CGK733.
Supplementary Fig. 3
Karyotypes of the senescent cells induced to proliferate by CGK733.
Supplementary Fig. 4
Effects of CGK733 on ATM and ATR kinase activities inside cells.
Supplementary Fig. 5
Effects of ATM/ATR siRNAs and CGK733 on the proliferation of senescent cells.
Supplementary Fig. 6
Synthesis of KU-55933 and a CGK733-biotin derivative.
Supplementary Fig. 7
Effects of KU-55933 on replicative senescence.
Supplementary Methods
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