In This Issue - pv
doi:10.1038/nchembio0706-v
Table of contents
July 2006, Volume 2 No 7 pp347-390
About the coverTop of page
Editorial
Walking the walk - p347
doi:10.1038/nchembio0706-347
Full Text - Walking the walk | PDF (74 KB) - Walking the walk
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News and Views
One-electron oxidation of DNA and inflammation processes - pp348 - 349
Jean Cadet, Thierry Douki & Jean-Luc Ravanat
doi:10.1038/nchembio0706-348
Nitrosoperoxycarbonate anion, a reactive species generated in inflammation processes, is able to specifically oxidize guanine bases with a sequence selectivity that is almost opposite from that usually observed for one-electron oxidants.
Full Text - One-electron oxidation of DNA and inflammation processes | PDF (149 KB) - One-electron oxidation of DNA and inflammation processes
See also: Brief Communication by Margolin et al.
NO place to hide - pp349 - 350
Nathaniel Finney
doi:10.1038/nchembio0706-349
Nitric oxide (NO) regulates a broad range of biological processes, yet many intracellular details of NO-mediated processes remain hidden. A new fluorescein derivative capable of direct detection provides a key advance in determining NO function in vivo.
Full Text - NO place to hide | PDF (167 KB) - NO place to hide
See also: Article by Lim et al.
Significance of one-bead-one-compound combinational chemistry - pp351 - 352
Xiaoyuan Chen & Sanjiv S Gambhir
doi:10.1038/nchembio0706-351
One-bead-one-compound combinatorial peptidomimetic libraries, in conjunction with a high-stringency screening method, are a powerful tool for screening peptide and peptidomimetic ligands for target proteins. Picomolar-affinity peptidomimetics for the integrin 
4
1 have now been developed and have been successfully used to image 41-expressing tumors in living mice.
Full Text - Significance of one-bead-one-compound combinational chemistry | PDF (646 KB) - Significance of one-bead-one-compound combinational chemistry
See also: Article by Peng et al.
Visualizing tricoordinate copper transfer - pp352 - 353
Paul A Cobine & Dennis R Winge
doi:10.1038/nchembio0706-352
Copper is a requisite cofactor in myriad cellular enzymes and is shuttled to different cellular sites for the assembly of copper-containing enzymes by Cu(I)-binding metallochaperones. NMR structural studies now reveal a key step in copper ion trafficking to sites of use.
Full Text - Visualizing tricoordinate copper transfer | PDF (199 KB) - Visualizing tricoordinate copper transfer
See also: Brief Communication by Banci et al.
Slip sliding away: new insights into DNA-protein recognition - pp353 - 354
Frederick W Dahlquist
doi:10.1038/nchembio0706-353
DNA-binding proteins accomplish the remarkable feat of finding their correct target sequences within a sea of genomic DNA. A new study uses NMR spectroscopy to show the mechanism by which proteins may hop between and slide along DNA as they search for their target binding sites.
Full Text - Slip sliding away: new insights into DNA-protein recognition | PDF (197 KB) - Slip sliding away: new insights into DNA-protein recognition
Discovery of a new 'dynasore' - pp355 - 356
Heather M Thompson & Mark A McNiven
doi:10.1038/nchembio0706-355
Dynamin is a large GTPase that participates in the severing of membrane-bound vesicles. A small-molecule inhibitor specific for the dynamin family of GTPases has been identified and reveals new aspects of membrane dynamics.
Full Text - Discovery of a new 'dynasore' | PDF (798 KB) - Discovery of a new 'dynasore'
Research Highlights - p357
doi:10.1038/nchembio0706-357
Full Text - Research Highlights | PDF (99 KB) - Research Highlights
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Perspective
Rational design of inhibitors that bind to inactive kinase conformations - pp358 - 364
Yi Liu & Nathanael S Gray
doi:10.1038/nchembio799
Abstract - Rational design of inhibitors that bind to inactive kinase conformations | Full Text - Rational design of inhibitors that bind to inactive kinase conformations | PDF (553 KB) - Rational design of inhibitors that bind to inactive kinase conformations
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Brief Communications
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation - pp365 - 366
Yelena Margolin, Jean-Francois Cloutier, Vladimir Shafirovich, Nicholas E Geacintov & Peter C Dedon
doi:10.1038/nchembio796
Abstract - Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation | Full Text - Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation | PDF (139 KB) - Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation | Supplementary information
See also: News and Views by Cadet et al.
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction - pp367 - 368
Lucia Banci, Ivano Bertini, Francesca Cantini, Isabella C Felli, Leonardo Gonnelli, Nick Hadjiliadis, Roberta Pierattelli, Antonio Rosato & Petros Voulgaris
doi:10.1038/nchembio797
Abstract - The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction | Full Text - The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction | PDF (219 KB) - The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction | Supplementary information
See also: News and Views by Cobine & Winge
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Letter
Small molecule–based reversible reprogramming of cellular lifespan - pp369 - 374
Jaejoon Won, Mina Kim, Nuri Kim, Jin Hee Ahn, Woo Gil Lee, Sung Soo Kim, Ki-Young Chang, Yong-Weon Yi & Tae Kook Kim
doi:10.1038/nchembio800
First Paragraph - Small molecule-based reversible reprogramming of cellular lifespan | Full Text - Small molecule–based reversible reprogramming of cellular lifespan | PDF (652 KB) - Small molecule–based reversible reprogramming of cellular lifespan | Supplementary information | Chemical compounds
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Combinatorial chemistry identifies high-affinity peptidomimetics against
Articles
Visualization of nitric oxide in living cells by a copper-based fluorescent probe - pp375 - 380
Mi Hee Lim, Dong Xu & Stephen J Lippard
doi:10.1038/nchembio794
Abstract - Visualization of nitric oxide in living cells by a copper-based fluorescent probe | Full Text - Visualization of nitric oxide in living cells by a copper-based fluorescent probe | PDF (312 KB) - Visualization of nitric oxide in living cells by a copper-based fluorescent probe | Supplementary information | Chemical compounds
See also: News and Views by Finney
Combinatorial chemistry identifies high-affinity peptidomimetics against 
4
1 integrin for in vivo tumor imaging - pp381 - 389
Li Peng, Ruiwu Liu, Jan Marik, Xiaobing Wang, Yoshikazu Takada & Kit S Lam
doi:10.1038/nchembio798
Abstract - Combinatorial chemistry identifies high-affinity peptidomimetics against [alpha]4[beta]1 integrin for in vivo tumor imaging | Full Text - Combinatorial chemistry identifies high-affinity peptidomimetics against 41 integrin for in vivo tumor imaging | PDF (551 KB) - Combinatorial chemistry identifies high-affinity peptidomimetics against 41 integrin for in vivo tumor imaging | Supplementary information | Chemical compounds
See also: News and Views by Chen & Gambhir
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Top of pageErratum
Erratum: The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography - p390
Georg Wille, Danilo Meyer, Andrea Steinmetz, Erik Hinze, Ralph Golbik & Kai Tittmann
doi:10.1038/nchembio0706-390
Full Text - Erratum: The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography | PDF (45 KB) - Erratum: The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography
