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Nature Chemical Biology 2, 303 (1 June 2006) | doi:10.1038/nchembio0606-303
Research Highlights
Abstract
Migrate ThiS Thiamine diphosphate (ThDP), the active metabolite of vitamin B1, is an enzymatic cofactor involved in carbon-transfer chemistry in the cell (see p. 324). Because of the unusual heterocyclic structure of ThDP, its biosynthesis has fascinated chemists for decades.
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