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Nature Chemical Biology 2, 294–295 (1 June 2006) | doi:10.1038/nchembio0606-294
Snapshots of three intermediates at the active site of pyruvate oxidase
Abstract
In all living cells, thiamine is essential in energy metabolism. Thiamine diphosphate (ThDP) is an essential cofactor for the metabolism of pyruvate, the end product of the glycolytic pathway; for the metabolism of α-ketoglutarate, a central intermediate in the tricarboxylic acid pathway; and for the conversion of fructose-6-phosphate and xylulose-5-phosphate, intermediates in carbohydrate metabolism.
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